HMGA2-induced epithelial-mesenchymal transition is reversed by let-7d in intrauterine adhesions.
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ABSTRACT:
SUBMITTER: Song M
PROVIDER: S-EPMC7864003 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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HMGA2-induced epithelial-mesenchymal transition is reversed by let-7d in intrauterine adhesions.
Song Minmin M Cao Chenrui C Zhou Zhenhua Z Yao Simin S Jiang Peipei P Wang Huiyan H Zhao Guangfeng G Hu Yali Y
Molecular human reproduction 20210201 2
Intrauterine adhesions (IUAs), the leading cause of uterine infertility, are characterized by endometrial fibrosis. The management of IUA is challenging because the pathogenesis of the disease largely unknown. In this study, we demonstrate that the mRNA and protein levels of high mobility group AT-hook 2 (HMGA2) were increased by nearly 3-fold (P < 0.0001) and 5-fold (P = 0.0095) in the endometrial epithelial cells (EECs) of IUA patients (n = 18) compared to controls. In vivo and in vitro models ...[more]
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