Ontology highlight
ABSTRACT:
SUBMITTER: McClafferty H
PROVIDER: S-EPMC7864050 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
McClafferty Heather H Runciman Hamish H Shipston Michael J MJ
The Journal of biological chemistry 20200910 49
<i>S</i>-Acylation, the reversible post-translational lipid modification of proteins, is an important mechanism to control the properties and function of ion channels and other polytopic transmembrane proteins. However, although increasing evidence reveals the role of diverse acyl protein transferases (zDHHC) in controlling ion channel <i>S</i>-acylation, the acyl protein thioesterases that control ion channel deacylation are very poorly defined. Here we show that ABHD17a (α/β-hydrolase domain-c ...[more]