Dataset Information

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.

ABSTRACT:

Background

Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV.

Methods

In this cross-sectional study, HIV-infected adults were randomly recruited across 17 HIV clinics in the Western Cape Province. Homeostatic model assessment for insulin resistance (HOMA-IR), hypertension, diabetes, metabolic syndrome by Joint Interim Statement criteria (JIS-MS), a ?5% and ?10% predicted risk for a CVD event within 10 years by the Framingham risk score (10-years-CVD risk) were computed. Associations between GGT and cardio-metabolic trait were explored using linear and binomial logistic regressions adjusted for age, gender, lifestyle behaviours and HIV-related characteristics.

Results

Among 709 participants (561 women, mean age 38.6 years), log-GGT was positively associated with waist circumference (?=2.75; p<0.001), diastolic blood pressure (?=1.65; p=0.006), total cholesterol (?=0.21; p<0.001), low-density lipoprotein-cholesterol (?=0.16; p<0.001), high-density lipoprotein-cholesterol and log-triglycerides (both ?=0.12; p<0.001), fasting plasma glucose (?=0.19; p=0.031), 2-hour-post-glucose-load plasma glucose (?=0.26; p=0.007), HOMA-IR (?=0.13; p=0.001), log-high-sensitivity C-reactive-protein (?=0.3; p<0.001) in linear regression analyses; with hypertension [OR=1.41 (95%CI, 1.13-1.75); p=0.001], JIS-MS [OR=1.33 (1.05-1.68); p=0.016], ?5% 10-year-CVD risk [OR=1.55 (1.24-1.9400); p<0.001] and ?10% 10-year-CVD risk [OR=1.56 (1.08-2.23); p=0.016] but not with diabetes [OR=1.24 (0.88-1.71), p=0.205] in logistic regression analyses.

Conclusions

In this study, GGT levels were associated with cardio-metabolic variables independent of HIV specific attributes. If confirmed in longitudinal studies, GGT evaluation maybe included in CVD risk monitoring strategies in people living with HIV.

SUBMITTER: Nguyen KA

PROVIDER: S-EPMC7864415 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.

Nguyen Kim A KA Peer Nasheeta N Kengne Andre P AP

PloS one 20210205 2

<h4>Background</h4>Gamma-glutamyl transferase (GGT) has recently been reported as a biomarker for cardiovascular (CVD) risk in general populations. We investigated the associations of GGT with cardio-metabolic diseases and CVD risk in South Africans living with HIV.<h4>Methods</h4>In this cross-sectional study, HIV-infected adults were randomly recruited across 17 HIV clinics in the Western Cape Province. Homeostatic model assessment for insulin resistance (HOMA-IR), hypertension, diabetes, meta ...[more]

PMID: 33544719

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Dataset Information

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.

Background

Methods

Results

Conclusions

Publications

Associations of gamma-glutamyl transferase with cardio-metabolic diseases in people living with HIV infection in South Africa.

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