Dataset Information
Co-expression of intermediate filaments glial fibrillary acidic protein and cytokeratin in pituitary adenoma.
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ABSTRACT: Purpose
To analyze the co-expression of the intermediate filaments GFAP and cytokeratin in 326 pituitary adenomas with regard to the distribution pattern, the subtype of the adenoma and clinical prognostic data.Methods
Tissue from 326 pituitary adenomas and 13 normal anterior pituitaries collected in the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, between 2006 and 2009 was investigated by immunohistochemistry, immunofluorescence and electron microscopy.Results
Co-expression of intermediate filaments GFAP and cytokeratin was associated with hormone expression in 62/278 cases (22%), but only found in 2/48 (4%) of null cell adenomas (p?ConclusionsCellular co-expression of the intermediate filaments GFAP and cytokeratin in pituitary adenomas and the pituitary was demonstrated and shown to be associated with hormone expression and low recurrence rate. The results are discussed with regard to the biology of folliculostellate cells, neural transformation and tumor stem cells. This study may complement the understanding of pituitary adenoma biology.
SUBMITTER: Wiesnagrotzki N
PROVIDER: S-EPMC7864846 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Co-expression of intermediate filaments glial fibrillary acidic protein and cytokeratin in pituitary adenoma.
Pituitary 20201001 1
<h4>Purpose</h4>To analyze the co-expression of the intermediate filaments GFAP and cytokeratin in 326 pituitary adenomas with regard to the distribution pattern, the subtype of the adenoma and clinical prognostic data.<h4>Methods</h4>Tissue from 326 pituitary adenomas and 13 normal anterior pituitaries collected in the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, between 2006 and 2009 was investigated by immunohistochemistry, immunofluorescence and electron microsco ...[more]