Dataset Information

Genetic and environmental architecture of conscientiousness in adolescence.

ABSTRACT: Using a genetically informative design (about 2000 twin pairs), we investigated the phenotypic and genetic and environmental architecture of a broad construct of conscientiousness (including conscientiousness per se, effortful control, self-control, and grit). These four different measures were substantially correlated; the coefficients ranged from 0.74 (0.72-0.76) to 0.79 (0.76-0.80). Univariate genetic analyses revealed that individual differences in conscientiousness measures were moderately attributable to additive genetic factors, to an extent ranging from 62 (58-65) to 64% (61-67%); we obtained no evidence that shared environmental influences were observed. Multivariate genetic analyses showed that for the four measures used to assess conscientiousness, genetic correlations were stronger than the corresponding non-shared environmental correlations, and that a latent common factor accounted for over 84% of the genetic variance. Our findings suggest that individual differences in the four measures of conscientiousness are not distinguishable at both the phenotypic and behavioural genetic levels, and that the overlap was substantially attributable to genetic factors.

SUBMITTER: Takahashi Y

PROVIDER: S-EPMC7864923 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Genetic and environmental architecture of conscientiousness in adolescence.

Takahashi Yusuke Y Zheng Anqing A Yamagata Shinji S Ando Juko J

Scientific reports 20210205 1

Using a genetically informative design (about 2000 twin pairs), we investigated the phenotypic and genetic and environmental architecture of a broad construct of conscientiousness (including conscientiousness per se, effortful control, self-control, and grit). These four different measures were substantially correlated; the coefficients ranged from 0.74 (0.72-0.76) to 0.79 (0.76-0.80). Univariate genetic analyses revealed that individual differences in conscientiousness measures were moderately ...[more]

PMID: 33547339

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Project description:Social-communication abilities are heritable traits, and their impairments overlap with the autism continuum. To characterise the genetic architecture of social-communication difficulties developmentally and identify genetic links with the autistic dimension, we conducted a genome-wide screen of social-communication problems at multiple time-points during childhood and adolescence.Social-communication difficulties were ascertained at ages 8, 11, 14 and 17 years in a UK population-based birth cohort (Avon Longitudinal Study of Parents and Children; N???5,628) using mother-reported Social Communication Disorder Checklist scores. Genome-wide Complex Trait Analysis (GCTA) was conducted for all phenotypes. The time-points with the highest GCTA heritability were subsequently analysed for single SNP association genome-wide. Type I error in the presence of measurement relatedness and the likelihood of observing SNP signals near known autism susceptibility loci (co-location) were assessed via large-scale, genome-wide permutations. Association signals (P???10-5) were also followed up in Autism Genetic Resource Exchange pedigrees (N?=?793) and the Autism Case Control cohort (Ncases/Ncontrols?=?1,204/6,491).GCTA heritability was strongest in childhood (h2(8 years)?=?0.24) and especially in later adolescence (h2(17 years)?=?0.45), with a marked drop during early to middle adolescence (h2(11 years)?=?0.16 and h2(14 years)?=?0.08). Genome-wide screens at ages 8 and 17 years identified for the latter time-point evidence for association at 3p22.2 near SCN11A (rs4453791, P?=?9.3?×?10-9; genome-wide empirical P?=?0.011) and suggestive evidence at 20p12.3 at PLCB1 (rs3761168, P?=?7.9?×?10-8; genome-wide empirical P?=?0.085). None of these signals contributed to risk for autism. However, the co-location of population-based signals and autism susceptibility loci harbouring rare mutations, such as PLCB1, is unlikely to be due to chance (genome-wide empirical Pco-location?=?0.007).Our findings suggest that measurable common genetic effects for social-communication difficulties vary developmentally and that these changes may affect detectable overlaps with the autism spectrum.

Dataset Information

Genetic and environmental architecture of conscientiousness in adolescence.

Publications

Genetic and environmental architecture of conscientiousness in adolescence.

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