Ontology highlight
ABSTRACT:
SUBMITTER: Braga TT
PROVIDER: S-EPMC7864962 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Braga Tarcio Teodoro TT Davanso Mariana Rodrigues MR Mendes Davi D de Souza Tiago Antonio TA de Brito Anderson Fernandes AF Cruz Mario Costa MC Hiyane Meire Ioshie MI de Lima Dhemerson Souza DS Nunes Vinicius V de Fátima Giarola Juliana J Souto Denio Emanuel Pires DEP Próchnicki Tomasz T Lauterbach Mario M Biscaia Stellee Marcela Petris SMP de Freitas Rilton Alves RA Curi Rui R Pontillo Alessandra A Latz Eicke E Camara Niels Olsen Saraiva NOS
Cell death & disease 20210205 2
Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Despite being inert in human cells, UA in its soluble form (sUA) can increase the level of interleukin-1β (IL-1β) in murine macrophages. We, therefore, hypothesized that the recognition of sUA is achieved by the Naip1-Nlrp3 inflammasome platform. Through structural modelling pred ...[more]