Ontology highlight
ABSTRACT:
SUBMITTER: Dufies M
PROVIDER: S-EPMC7865059 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Dufies Maeva M Verbiest Annelies A Cooley Lindsay S LS Ndiaye Papa Diogop PD He Xingkang X Nottet Nicolas N Souleyreau Wilfried W Hagege Anais A Torrino Stephanie S Parola Julien J Giuliano Sandy S Borchiellini Delphine D Schiappa Renaud R Mograbi Baharia B Zucman-Rossi Jessica J Bensalah Karim K Ravaud Alain A Auberger Patrick P Bikfalvi Andréas A Chamorey Emmanuel E Rioux-Leclercq Nathalie N Mazure Nathalie M NM Beuselinck Benoit B Cao Yihai Y Bernhard Jean Christophe JC Ambrosetti Damien D Pagès Gilles G
Communications biology 20210205 1
Polo-like kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstrated that a HIF-2-dependent regulatory pathway drives Plk1 expression in clear cell renal cell carcinoma (ccRCC). Mechanistically, HIF-2 transcriptionally targets the hypoxia response element of the P ...[more]