Ontology highlight
ABSTRACT:
SUBMITTER: Mello CA
PROVIDER: S-EPMC7865637 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Mello Celso Abdon CA Campos Fernando Augusto Batista FAB Santos Tiago Goss TG Silva Maria Leticia Gobo MLG Torrezan Giovana Tardin GT Costa Felipe D'Almeida FD Formiga Maria Nirvana MN Nicolau Ulisses U Nascimento Antonio Geraldo AG Silva Cassia C Curado Maria Paula MP Nakagawa Suely Akiko SA Lopes Ademar A Aguiar Samuel S
Cancers 20210128 3
Desmoplastic small round cell tumor (DSRCT) is an extremely rare, aggressive sarcoma affecting adolescents and young adults with male predominance. Generally, it originates from the serosal surface of the abdominal cavity. The hallmark characteristic of DSRCT is the EWSR1-WT1 gene fusion. This translocation up-regulates the expression of PDGFRα, VEGF and other proteins related to tumor and vascular cell proliferation. Current management of DSRCT includes a combination of chemotherapy, radiation ...[more]