ID1 and ID4 Are Biomarkers of Tumor Aggressiveness and Poor Outcome in Immunophenotypes of Breast Cancer.
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ABSTRACT:
SUBMITTER: Garcia-Escolano M
PROVIDER: S-EPMC7865969 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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ID1 and ID4 Are Biomarkers of Tumor Aggressiveness and Poor Outcome in Immunophenotypes of Breast Cancer.
Garcia-Escolano Marta M Montoyo-Pujol Yoel G YG Ortiz-Martinez Fernando F Ponce Jose J JJ Delgado-Garcia Silvia S Martin Tina A TA Ballester Hortensia H Aranda F Ignacio FI Castellon-Molla Elena E Sempere-Ortells J Miguel JM Peiro Gloria G
Cancers 20210127 3
Inhibitor of differentiation (ID) proteins are a family of transcription factors that contribute to maintaining proliferation during embryogenesis as they avoid cell differentiation. Afterward, their expression is mainly silenced, but their reactivation and contribution to tumor development have been suggested. In breast cancer (BC), the overexpression of ID1 has been previously described. However, whether the remaining <i>ID</i> genes have a specific role in this neoplasia is still unclear. We ...[more]
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