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Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability.

ABSTRACT: Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and ?-? stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy.

SUBMITTER: Kim KN

PROVIDER: S-EPMC7866127 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability.

Kim Kyoung Nan KN Oh Keun Sang KS Shim Jiwook J Schlaepfer Isabel R IR Karam Sana D SD Lee Jung-Jae JJ

Polymers 20210126 3

Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of ...[more]

PMID: 33530388

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