Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Brouchet A
PROVIDER: S-EPMC7866157 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Gomez-Brouchet Anne A Gilhodes Julia J Acker Nathalie Van NV Brion Regis R Bouvier Corinne C Assemat Pauline P Gaspar Nathalie N Aubert Sebastien S Guinebretiere Jean-Marc JM Marie Beatrice B Larousserie Frederique F Entz-Werlé Natacha N Pinieux Gonzague de G Mascard Eric E Gouin Francois F Brousset Pierre P Tabone Marie-Dominique MD Jimenez Marta M Le Deley Marie-Cecile MC Blay Jean-Yves JY Brugieres Laurence L Piperno-Neumann Sophie S Rédini Francoise F
Cancers 20210123 3
Biological and histopathological techniques identified osteoclasts and macrophages as targets of zoledronic acid (ZA), a therapeutic agent that was detrimental for patients in the French OS2006 trial. Conventional and multiplex immunohistochemistry of microenvironmental and OS cells were performed on biopsies of 124 OS2006 patients and 17 surgical ("OSNew") biopsies respectively. CSF-1R (common osteoclast/macrophage progenitor) and TRAP (osteoclast activity) levels in serum of 108 patients were ...[more]