Dataset Information

Fabrication of an Extremely Cheap Poly(3,4-ethylenedioxythiophene) Modified Pencil Lead Electrode for Effective Hydroquinone Sensing.

ABSTRACT: Hydroquinone (HQ) is one of the major deleterious metabolites of benzene in the human body, which has been implicated to cause various human diseases. In order to fabricate a feasible sensor for the accurate detection of HQ, we attempted to electrochemically modify a piece of common 2B pencil lead (PL) with the conductive poly(3,4-ethylenedioxythiophene) or PEDOT film to construct a PEDOT/PL electrode. We then examined the performance of PEDOT/PL in the detection of hydroquinone with different voltammetry methods. Our results have demonstrated that PEDOT film was able to dramatically enhance the electrochemical response of pencil lead electrode to hydroquinone and exhibited a good linear correlation between anodic peak current and the concentration of hydroquinone by either cyclic voltammetry or linear sweep voltammetry. The influences of PEDOT film thickness, sample pH, voltammetry scan rate, and possible chemical interferences on the measurement of hydroquinone have been discussed. The PEDOT film was further characterized by SEM with EDS and FTIR spectrum, as well as for stability with multiple measurements. Our results have demonstrated that the PEDOT modified PL electrode could be an attractive option to easily fabricate an economical sensor and provide an accurate and stable approach to monitoring various chemicals and biomolecules.

SUBMITTER: Lu JY

PROVIDER: S-EPMC7866211 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Fabrication of an Extremely Cheap Poly(3,4-ethylenedioxythiophene) Modified Pencil Lead Electrode for Effective Hydroquinone Sensing.

Lu Jian-Yu JY Yu Yu-Sheng YS Chen Tung-Bo TB Chang Chiung-Fen CF Tamulevičius Sigitas S Erts Donats D Wu Kevin C-W KC Gu Yesong Y

Polymers 20210122 3

Hydroquinone (HQ) is one of the major deleterious metabolites of benzene in the human body, which has been implicated to cause various human diseases. In order to fabricate a feasible sensor for the accurate detection of HQ, we attempted to electrochemically modify a piece of common 2B pencil lead (PL) with the conductive poly(3,4-ethylenedioxythiophene) or PEDOT film to construct a PEDOT/PL electrode. We then examined the performance of PEDOT/PL in the detection of hydroquinone with different v ...[more]

PMID: 33498983

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Project description:Electrical microstimulation has shown promise in restoring neural deficits in humans. Electrodes coated with materials like the conducting polymer poly(3,4‐ethylenedioxythiophene) doped with acid‐functionalized carbon nanotubes (PEDOT/CNTs, or PC) exhibit superior charge injection than traditional metals like platinum. However, the stimulation performance of PC remains to be fully characterized. Advanced imaging techniques and transgenic tools allow for real‐time observations of neural activity in vivo. Herein, microelectrodes coated with PC and iridium oxide (IrOx) (a commonly used high‐charge‐injection material) are implanted in GCaMP6s mice and electrical stimulation is applied while imaging neuronal calcium responses. Results show that PC‐coated electrodes stimulate more intense and broader GCaMP responses than IrOx. Two‐photon microscopy reveals that PC‐coated electrodes activate significantly more neuronal soma and neuropil than IrOx‐coated electrodes in constant‐voltage stimulation and significantly more neuronal soma in constant‐current stimulation. Furthermore, with the same injected charge, both materials activate more spatially confined neural elements with shorter pulses than longer pulses, providing a means to tune stimulation selectivity. Finite element analyses reveal that the PC coating creates a denser and nonuniform electric field, increasing the likelihood of activating nearby neural elements. PC coating can significantly improve energy efficiency for electrical stimulation applications. The stimulation performance of two high‐charge‐injection materials poly(3,4‐ethylenedioxythiophene) doped with acid‐functionalized carbon nanotube (PEDOT/CNT) and iridium oxide is examined. In vivo imaging results show that PEDOT/CNT is a more energy‐efficient material for cortical activation. In addition, for both materials, shorter stimulation pulses activate more spatially distinct neural elements than longer pulses, providing a means to tune stimulation selectivity.© 2021 WILEY‐VCH GmbH

Project description:Magnesium (Mg) is a promising biodegradable implant material because of its appropriate mechanical properties and safe degradation products. However, in vivo corrosion speed and hydrogen gas production need to be controlled for uses in biomedical applications. Here we report the development of a conducting polymer 3,4-ethylenedioxythiphene (PEDOT) and graphene oxide (GO) composite coating as a corrosion control layer. PEDOT/GO was electropolymerized on Mg samples in ethanol media. The coated Mg samples were subjected to various corrosion tests. The PEDOT/GO coating significantly reduced the rate of corrosion as evidenced by lower Mg ion concentration and pH of the corrosion media. In addition, the coating decreased the evolved hydrogen. Electrochemical analysis of the corroding samples showed more positive corrosion potential, a decreased corrosion current, and an increase in the polarization resistance. PEDOT/GO corrosion protection is attributed to three factors; an initial passive layer preventing solution ingress, buildup of negative charges in the film, and formation of corrosion protective Mg phosphate layer through redox coupling with Mg corrosion. To explore the biocompatibility of the coated implants in vitro, corrosion media from PEDOT/GO coated or uncoated Mg samples were exposed to cultured neurons where PEDOT/GO coated samples showed decreased toxicity. These results suggest that PEDOT/GO coating will be an effective treatment for controlling corrosion of Mg based medical implants.Coating Mg substrates with a PEDOT/GO composite coating showed a significant decrease in corrosion rate. While conducting polymer coatings have been used to prevent corrosion on various metals, there has been little work on the use of these coatings for Mg. Additionally, to our knowledge, there has not been a report of the combined used of conducting polymer and GO as a corrosion control layer. Corrosion control is attributed to an initial barrier layer followed by electrochemical coupling of the PEDOT/GO coating with the substrate to facilitate the formation of a protective phosphate layer. This coupling also resulted in a decrease in hydrogen produced during corrosion, which could further improve the host tissue integration of Mg implants. This work elaborates on the potential for electroactive polymers to serve as corrosion control methods.

Dataset Information

Fabrication of an Extremely Cheap Poly(3,4-ethylenedioxythiophene) Modified Pencil Lead Electrode for Effective Hydroquinone Sensing.

Publications

Fabrication of an Extremely Cheap Poly(3,4-ethylenedioxythiophene) Modified Pencil Lead Electrode for Effective Hydroquinone Sensing.

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