Dataset Information
Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study.
Ontology highlight
ABSTRACT: Background
Few studies have evaluated associations between pesticides and hyperthyroidism.Objective
We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study.Methods
We used Cox proportional hazards models to estimate HRs and 95% CIs for associations between pesticide use at enrolment and hyperthyroidism (n=271) in 35?150 applicators (mostly men), adjusting for potential confounders.Results
Ever use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ?62 years) was associated with reduced hyperthyroidism risk, with HRs ranging from 0.50 (95% CI 0.30 to 0.83) for maneb/mancozeb to 0.77 (95% CI 0.59 to 1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensity-weighted lifetime days of using carbofuran and chlorpyrifos (ptrend ?0.05).Conclusions
Observed associations between pesticides and decreased risk of hyperthyroidism warrant further investigation.
SUBMITTER: Shrestha S
PROVIDER: S-EPMC7866491 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study.
Occupational and environmental medicine 20190225 5
<h4>Background</h4>Few studies have evaluated associations between pesticides and hyperthyroidism.<h4>Objective</h4>We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study.<h4>Methods</h4>We used Cox proportional hazards models to estimate HRs and 95% CIs for associations between pesticide use at enrolment and hyperthyroidism (n=271) in 35 150 applicators (mostly men), adjusting for potential confounders ...[more]