Ontology highlight
ABSTRACT:
SUBMITTER: Lafouresse F
PROVIDER: S-EPMC7867409 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
eLife 20210111
Cytotoxic immune cells are endowed with a high degree of heterogeneity in their lytic function, but how this heterogeneity is generated is still an open question. We therefore investigated if human CD8<sup>+</sup> T cells could segregate their lytic components during telophase, using imaging flow cytometry, confocal microscopy, and live-cell imaging. We show that CD107a<sup>+</sup>-intracellular vesicles, perforin, and granzyme B unevenly segregate in a constant fraction of telophasic cells duri ...[more]