Dataset Information

Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project.

ABSTRACT:

Purpose

We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood.

Methods

Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method.

Results

Data were available for 325 children. Children consumed on average 332 kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100 kcal from total sugar per day was significantly associated with a z score HDL-C decrease (- 0.14; 95% CI - 0.01, - 0.27; p value?=?0.031). Concerning different food groups of total sugar intake, 100 kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (- 1.67; 95% CI - 0.42, - 2.91; p value?=?0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value?=?0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake.

Conclusion

Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease.

Clinical trial registry

ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1 .

SUBMITTER: Aumueller N

PROVIDER: S-EPMC7867537 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project.

Aumueller Nicole N Gruszfeld Dariusz D Gradowska Kinga K Escribano Joaquín J Ferré Natalia N Martin Françoise F Poncelet Pascale P Verduci Elvira E ReDionigi Alice A Koletzko Berthold B Grote Veit V

European journal of nutrition 20200506 1

<h4>Purpose</h4>We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood.<h4>Methods</h4>Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8 years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake compri ...[more]

PMID: 32377804

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Dataset Information

Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project.

Purpose

Methods

Results

Conclusion

Clinical trial registry

Publications

Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project.

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