Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.
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ABSTRACT:
SUBMITTER: Atkinson EG
PROVIDER: S-EPMC7867648 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.
Atkinson Elizabeth G EG Maihofer Adam X AX Kanai Masahiro M Martin Alicia R AR Karczewski Konrad J KJ Santoro Marcos L ML Ulirsch Jacob C JC Kamatani Yoichiro Y Okada Yukinori Y Finucane Hilary K HK Koenen Karestan C KC Nievergelt Caroline M CM Daly Mark J MJ Neale Benjamin M BM
Nature genetics 20210118 2
Admixed populations are routinely excluded from genomic studies due to concerns over population structure. Here, we present a statistical framework and software package, Tractor, to facilitate the inclusion of admixed individuals in association studies by leveraging local ancestry. We test Tractor with simulated and empirical two-way admixed African-European cohorts. Tractor generates accurate ancestry-specific effect-size estimates and P values, can boost genome-wide association study (GWAS) po ...[more]
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