Ontology highlight
ABSTRACT:
SUBMITTER: Chen SH
PROVIDER: S-EPMC7868597 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chen Stephanie H SH Scott Xavier O XO Ferrer Marcelo Yoandy Y Almeida Vania W VW Blackwelder Patricia L PL Yavagal Dileep R DR Peterson Eric C EC Starke Robert M RM Dietrich W Dalton WD Keane Robert W RW de Rivero Vaccari Juan Pablo JP
Frontiers in pharmacology 20210122
The inflammatory response appears to play a critical role in clotting in which neutrophil extracellular traps (NETs) are the major drivers of thrombosis in acute ischemic stroke (AIS). The inflammasome is an innate immune complex involved in the activation of interleukin (IL)-18 and IL-1β through caspase-1, but whether the inflammasome plays a role in NETosis in AIS remains poorly understood. Here we assessed the levels of inflammasome signaling proteins in NETs and their association with clinic ...[more]