Ontology highlight
ABSTRACT:
SUBMITTER: Gorur A
PROVIDER: S-EPMC7868999 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Gorur Aysegul A Bayraktar Recep R Ivan Cristina C Mokhlis Hamada Ahmed HA Bayraktar Emine E Kahraman Nermin N Karakas Didem D Karamil Selda S Kabil Nashwa N NN Kanlikilicer Pinar P Aslan Burcu B Tamer Lulufer L Wang Zhihui Z Cristini Vittorio V Lopez-Berestein Gabriel G Calin George G Ozpolat Bulent B
Molecular therapy. Nucleic acids 20210120
Deregulation of noncoding RNAs, including microRNAs (miRs), is implicated in the pathogenesis of many human cancers, including breast cancer. Through extensive analysis of The Cancer Genome Atlas, we found that expression of miR-22-3p is markedly lower in triple-negative breast cancer (TNBC) than in normal breast tissue. The restoration of miR-22-3p expression led to significant inhibition of TNBC cell proliferation, colony formation, migration, and invasion. We demonstrated that miR-22-3p reduc ...[more]