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Hypercoagulopathy in Severe COVID-19: Implications for Acute Care.

ABSTRACT: COVID-19 was first described in late 2019 and has since developed into a pandemic affecting more than 21 million people worldwide. Of particular relevance for acute care is the occurrence of COVID-19-associated coagulopathy (CAC), which is characterised by hypercoagulability, immunothrombosis and venous thromboembolism, and contributes to hypoxia in a significant proportion of patients. This review describes diagnosis and treatment of CAC in the emergency department and in intensive care. We summarise the pathological mechanisms and common complications of CAC such as pulmonary thrombosis and venous thromboembolic events and discuss current strategies for thromboprophylaxis and therapeutic anti-coagulation in the acute care setting.

SUBMITTER: Waite AAC

PROVIDER: S-EPMC7869057 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Hypercoagulopathy in Severe COVID-19: Implications for Acute Care.

Waite Alicia A C AAC Hamilton David O DO Pizzi Roberto R Ageno Walter W Welters Ingeborg D ID

Thrombosis and haemostasis 20201223 12

COVID-19 was first described in late 2019 and has since developed into a pandemic affecting more than 21 million people worldwide. Of particular relevance for acute care is the occurrence of COVID-19-associated coagulopathy (CAC), which is characterised by hypercoagulability, immunothrombosis and venous thromboembolism, and contributes to hypoxia in a significant proportion of patients. This review describes diagnosis and treatment of CAC in the emergency department and in intensive care. We sum ...[more]

PMID: 33368088

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