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Antibacterial Thiamine inspired silver (I) and gold (I) N-heterocyclic carbene compounds.

ABSTRACT: Three new coinage metal carbene complexes of silver and gold were synthesized from a thiamine inspired proligand. The compounds were characterized by HRMS, NMR spectroscopy (1H, 19F, 31P and 13C), FT-IR and elemental analysis. The coordination environment around the metal centers was correlated to the diffusion coefficients obtained from DOSY-NMR experiments and was in agreement with the nuclearity observed in the solid-state by single crystal X-ray crystallography. The silver and gold carbene compounds were subjected to MIC studies against a panel of pathogenic bacteria, including multidrug resistant strains, with the gold carbene derivative showing the most potent antimicrobial activity against Gram-positive methicillin resistant Staphylococcus aureus (MRSA).

SUBMITTER: Esarte Palomero O

PROVIDER: S-EPMC7869835 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Antibacterial Thiamine inspired silver (I) and gold (I) N-heterocyclic carbene compounds.

Esarte Palomero Orhi O Cunningham Ashley L AL Davies Bryan W BW Jones Richard A RA

Inorganica chimica acta 20201127

Three new coinage metal carbene complexes of silver and gold were synthesized from a thiamine inspired proligand. The compounds were characterized by HRMS, NMR spectroscopy (1H, 19F, 31P and 13C), FT-IR and elemental analysis. The coordination environment around the metal centers was correlated to the diffusion coefficients obtained from DOSY-NMR experiments and was in agreement with the nuclearity observed in the solid-state by single crystal X ...[more]

PMID: 33568836

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