Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation.
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ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC7870075 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Physicochemical properties and formulation development of a novel compound inhibiting Staphylococcus aureus biofilm formation.
Wang Nan N Qi Feng F Yu Haqing H Yestrepsky Bryan D BD Larsen Scott D SD Shi Honglan H Ji Juan J Anderson David W DW Li Hao H Sun Hongmin H
PloS one 20210208 2
The emergence of antibiotic resistance over the past several decades has given urgency to new antibacterial strategies that apply less selective pressure. A new class of anti-virulence compounds were developed that are active against methicillin-resistant Staphylococcus aureus (MRSA), by inhibiting bacterial virulence without hindering their growth to reduce the selective pressure for resistance development. One of the compounds CCG-211790 has demonstrated potent anti-biofilm activity against MR ...[more]
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