Ontology highlight
ABSTRACT:
SUBMITTER: Tanabe T
PROVIDER: S-EPMC7870409 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
The Journal of veterinary medical science 20201127 1
Alpha-amanitin, one of the amatoxins in egg amanita, has a cyclic peptide structure, and was reported as having antiviral activity against several viruses. We investigated whether α-amanitin has antiviral activity against feline immunodeficiency virus (FIV). FL-4 cells persistently infected with FIV Petaluma were cultured with α-amanitin. Reverse transcriptase (RT) activity in the supernatant of FL-4 cells was significantly inhibited by α-amanitin. In addition, the production of FIV core protein ...[more]