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ABSTRACT: Background
Some individuals with Parkinson's disease (PD) experience working memory and inhibitory difficulties, others learning and memory difficulties, while some only minimal to no cognitive deficits for many years.Objective
To statistically derive PD executive and memory phenotypes, and compare PD phenotypes on disease and demographic variables, vascular risk factors, and specific neuroimaging variables with known associations to executive and memory function relative to non-PD peers.Methods
Non-demented individuals with PD (n?=?116) and non-PD peers (n?=?62) were recruited to complete neuropsychology measures, blood draw, and structural magnetic resonance imaging. Tests representing the cognitive domains of interest (4 executive function, 3 memory) were included in a k-means cluster analysis comprised of the PD participants. Resulting clusters were compared demographic and disease-related variables, vascular risk markers, gray/white regions of interest, and white matter connectivity between known regions involved in executive and memory functions (dorsolateral prefrontal cortices to caudate nuclei; entorhinal cortices to hippocampi).Results
Clusters showed: 1) PD Executive, n?=?25; 2) PD Memory, n?=?35; 3) PD Cognitively Well; n?=?56. Even after disease variable corrections, PD Executive had less subcortical gray matter, white matter, and fewer bilateral dorsolateral-prefrontal cortex to caudate nucleus connections; PD Memory showed bilaterally reduced entorhinal-hippocampal connections. PD Cognitively Well showed only reduced putamen volume and right entorhinal cortex to hippocampi connections relative to non-PD peers. Groups did not statistically differ on cortical integrity measures or cerebrovascular disease markers.Conclusion
PD cognitive phenotypes showed different structural gray and white matter patterns. We discuss data relative to phenotype demographics, cognitive patterns, and structural brain profiles.
SUBMITTER: Crowley SJ
PROVIDER: S-EPMC7870551 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Crowley Samuel J SJ Banan Guita G Amin Manish M Tanner Jared J JJ Hizel Loren L Nguyen Peter P Brumback Babette B Rodriguez Katie K McFarland Nikolaus N Bowers Dawn D Ding Mingzhou M Mareci Thomas A TA Price Catherine C CC
Journal of Parkinson's disease 20210101 1
<h4>Background</h4>Some individuals with Parkinson's disease (PD) experience working memory and inhibitory difficulties, others learning and memory difficulties, while some only minimal to no cognitive deficits for many years.<h4>Objective</h4>To statistically derive PD executive and memory phenotypes, and compare PD phenotypes on disease and demographic variables, vascular risk factors, and specific neuroimaging variables with known associations to executive and memory function relative to non- ...[more]