Ontology highlight
ABSTRACT:
SUBMITTER: Ozono S
PROVIDER: S-EPMC7870668 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nature communications 20210208 1
The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the ACE2 receptor and is cleaved by TMPRSS2. However, whether S mutations affect SARS-CoV-2 cell entry remains unknown. Here, we show that naturally occurring S mutations can reduce or enhance cell entry via ACE2 and TMPRSS2. A SARS-CoV-2 S-pseudotyped lentivirus exhibits substantially lower entry than that of ...[more]