Ontology highlight
ABSTRACT:
SUBMITTER: Ozono S
PROVIDER: S-EPMC7870668 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Ozono Seiya S Zhang Yanzhao Y Ode Hirotaka H Sano Kaori K Tan Toong Seng TS Imai Kazuo K Miyoshi Kazuyasu K Kishigami Satoshi S Ueno Takamasa T Iwatani Yasumasa Y Suzuki Tadaki T Tokunaga Kenzo K
Nature communications 20210208 1
The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the ACE2 receptor and is cleaved by TMPRSS2. However, whether S mutations affect SARS-CoV-2 cell entry remains unknown. Here, we show that naturally occurring S mutations can reduce or enhance cell entry via ACE2 and TMPRSS2. A SARS-CoV-2 S-pseudotyped lentivirus exhibits substantially lower entry than that of ...[more]