Ontology highlight
ABSTRACT:
SUBMITTER: Song XL
PROVIDER: S-EPMC7870742 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Song Xing-Lei XL Liu Di-Shi DS Qiang Min M Li Qian Q Liu Ming-Gang MG Li Wei-Guang WG Qi Xin X Xu Nan-Jie NJ Yang Guang G Zhu Michael Xi MX Xu Tian-Le TL
Neuroscience bulletin 20200930 2
Acid-sensing ion channels (ASICs), the main H<sup>+</sup> receptors in the central nervous system, sense extracellular pH fluctuations and mediate cation influx. ASIC1a, the major subunit responsible for acid-activated current, is widely expressed in brain neurons, where it plays pivotal roles in diverse functions including synaptic transmission and plasticity. However, the underlying molecular mechanisms for these functions remain mysterious. Using extracellular epitope tagging and a novel anti ...[more]