Ontology highlight
ABSTRACT:
SUBMITTER: Samant PP
PROVIDER: S-EPMC7871333 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Samant Pradnya P PP Niedzwiecki Megan M MM Raviele Nicholas N Tran Vilinh V Mena-Lapaix Juan J Walker Douglas I DI Felner Eric I EI Jones Dean P DP Miller Gary W GW Prausnitz Mark R MR
Science translational medicine 20201101 571
Tissue interstitial fluid (ISF) surrounds cells and is an underutilized source of biomarkers that complements conventional sources such as blood and urine. However, ISF has received limited attention due largely to lack of simple collection methods. Here, we developed a minimally invasive, microneedle-based method to sample ISF from human skin that was well tolerated by participants. Using a microneedle patch to create an array of micropores in skin coupled with mild suction, we sampled ISF from ...[more]