Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients.

ABSTRACT:

Background

Pathological angiogenesis is involved in the development of hepatocellular carcinoma. In patients with chronic hepatitis C (CHC), the level of angiogenic factor angiopoietin (ANGP)-2 is reported to be increased in the blood, correlating with fibrosis. In this study, we aimed to clarify whether blood ANGP-2 is useful as a biomarker for liver angiogenesis and fibrosis in CHC patients and to further reveal the relationship between such pathology in a carbon tetrachloride (CCl₄)-treated liver fibrosis mouse model.

Methods

Plasma levels of ANGP-2, expression of a liver sinusoidal endothelial cell (LSEC) marker (CD31), collagen deposition (Sirius Red staining) in the liver, clinical fibrosis markers (Mac-2 binding protein glycosylation isomer, virtual touch q

SUBMITTER: Osawa Y 

PROVIDER: S-EPMC7871374 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature