Ontology highlight
ABSTRACT:
SUBMITTER: Delgado RN
PROVIDER: S-EPMC7871661 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20200401 6486
Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. Although morphogens initially establish NSC positional identity in the neural tube, it is unclear how such regional differences are maintained as the forebrain grows much larger and more anatomically complex. We found that the maintenance of NSC positional identity in the murine brain requires a <i>mixed-lineage leukemia 1</i> (<i>Mll1</i>)-dependent ...[more]