Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC7871731 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhou Wei W Zhao Zhangchen Z Nielsen Jonas B JB Fritsche Lars G LG LeFaive Jonathon J Gagliano Taliun Sarah A SA Bi Wenjian W Gabrielsen Maiken E ME Daly Mark J MJ Neale Benjamin M BM Hveem Kristian K Abecasis Goncalo R GR Willer Cristen J CJ Lee Seunggeun S
Nature genetics 20200518 6
With very large sample sizes, biobanks provide an exciting opportunity to identify genetic components of complex traits. To analyze rare variants, region-based multiple-variant aggregate tests are commonly used to increase power for association tests. However, because of the substantial computational cost, existing region-based tests cannot analyze hundreds of thousands of samples while accounting for confounders such as population stratification and sample relatedness. Here we propose a scalabl ...[more]