Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes.
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ABSTRACT:
SUBMITTER: Mavingire N
PROVIDER: S-EPMC7872014 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes.
Mavingire Nicole N Campbell Petreena P Wooten Jonathan J Aja Joyce J Davis Melissa B MB Loaiza-Perez Andrea A Brantley Eileen E
Cancer letters 20201209
Breast cancer stem cells (BCSCs) promote endocrine therapy (ET) resistance, also known as endocrine resistance in hormone receptor (HR) positive breast cancer. Endocrine resistance occurs via mechanisms that are not yet fully understood. In vitro, in vivo and clinical data suggest that signaling cascades such as Notch, hypoxia inducible factor (HIF), and integrin/Akt promote BCSC-mediated endocrine resistance. Once HR positive breast cancer patients relapse on ET, targeted therapy agents such as ...[more]
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