Ontology highlight
ABSTRACT:
SUBMITTER: Fiege JK
PROVIDER: S-EPMC7872261 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Fiege Jessica K JK Thiede Joshua M JM Nanda Hezkiel Arya HA Matchett William E WE Moore Patrick J PJ Montanari Noe Rico NR Thielen Beth K BK Daniel Jerry J Stanley Emma E Hunter Ryan C RC Menachery Vineet D VD Shen Steven S SS Bold Tyler D TD Langlois Ryan A RA
PLoS pathogens 20210128 1
The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse cell population contributes to elements of viral tropism and pathogenesis, antiviral immunity, and treatment response to remdesivir. We found that, while a variety of epithelial cell types are susceptible to infection, ciliated cells are the predominant cell target of SARS-CoV-2. The host protease TMPRSS2 was required f ...[more]