Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma.

ABSTRACT:

Background

Six cell surface receptors, human epidermal growth factor receptor-2 (Her-2), platelet-derived growth factor receptor-β (PDGFR-β), insulin-like growth factor-1 receptor (IGF-1R), insulin receptor (IR), c-Met, and vascular endothelial growth factor receptor-3 (VEGFR-3), previously demonstrated variable expression across varying patient-derived and standard osteosarcoma (OS) cell lines. The current study sought to validate previous expression patterns and evaluate whether these receptors offer prognostic and/or therapeutic value.

Methods

Patient-derived OS cell lines (n = 52) were labeled with antibodies to Her-2, PDGFR-β, IGF-1R, IR, c-Met, and VEGFR-3. Expression was characterized using flow cytometry. The difference in geometric mean f

SUBMITTER: Zvi Y 

PROVIDER: S-EPMC7872755 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature