Dataset Information

Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke.

ABSTRACT:

Background

Observational studies have shown an inverse association between circulating linoleic acid (LA) and risk of ischemic stroke (IS).

Objective

The aim of this study was to explore whether genetic variants predicting levels of circulating LA are associated with IS and its subtypes using a two-sample Mendelian randomization (MR) analysis.

Methods

LA-related single-nucleotide polymorphisms (SNPs) were selected from a genome-wide association study of 8,631 participants, and summary statistics of IS and IS subtypes were obtained from the MEGASTROKE consortium. MR analysis was performed using the inverse-variance weighted (IVW) method complemented with other approaches, including weighted-median, weighted-mode, MR Pleiotropy RESidual Sum and Outlier test and MR-Egger regression, to test for the robustness of the association. Moreover, we conducted bidirectional MR analysis to assess the impact of IS-associated SNPs on circulating LA levels. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.

Results

We found that genetically predicted circulating LA levels were inversely associated with the risk of IS by the IVW method (OR = 0.98, 95% CI: 0.97-0.99, and P = 0.003). Subgroup analyses showed a statistically significant association between LA and risk of large artery stroke (LAS; OR = 0.95, 95% CI: 0.92-0.98, and P = 0.004), but not for other IS subtypes. The results were stable in sensitivity analyses, and no evidence of reverse association between LA and risk of IS, or LAS was observed.

Conclusion

Our study supports a potential inverse association of genetically predicted circulating LA levels with risk of IS, particularly LAS.

SUBMITTER: Ye D

PROVIDER: S-EPMC7874191 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke.

Ye Ding D Huang Huijun H Wu David J H DJH Zhang Wanting W Zhou Feixiang F Qian Yu Y Zheng Jusheng J Mao Yingying Y

Frontiers in genetics 20210108

<h4>Background</h4>Observational studies have shown an inverse association between circulating linoleic acid (LA) and risk of ischemic stroke (IS).<h4>Objective</h4>The aim of this study was to explore whether genetic variants predicting levels of circulating LA are associated with IS and its subtypes using a two-sample Mendelian randomization (MR) analysis.<h4>Methods</h4>LA-related single-nucleotide polymorphisms (SNPs) were selected from a genome-wide association study of 8,631 participants, ...[more]

PMID: 33584789

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Project description:Although stroke centers are widely accepted and supported, little is known about their effect on patient outcomes.To examine the association between admission to stroke centers for acute ischemic stroke and mortality.Observational study using data from the New York Statewide Planning and Research Cooperative System. We compared mortality for patients admitted with acute ischemic stroke (n = 30,947) between 2005 and 2006 at designated stroke centers and nondesignated hospitals using differential distance to hospitals as an instrumental variable to adjust for potential prehospital selection bias. Patients were followed up for mortality for 1 year after the index hospitalization through 2007. To assess whether our findings were specific to stroke, we also compared mortality for patients admitted with gastrointestinal hemorrhage (n = 39,409) or acute myocardial infarction (n = 40,024) at designated stroke centers and nondesignated hospitals.Thirty-day all-cause mortality.Among 30,947 patients with acute ischemic stroke, 15,297 (49.4%) were admitted to designated stroke centers. Using the instrumental variable analysis, admission to designated stroke centers was associated with lower 30-day all-cause mortality (10.1% vs 12.5%; adjusted mortality difference, -2.5%; 95% confidence interval [CI], -3.6% to -1.4%; P < .001) and greater use of thrombolytic therapy (4.8% vs 1.7%; adjusted difference, 2.2%; 95% CI, 1.6% to 2.8%; P < .001). Differences in mortality also were observed at 1-day, 7-day, and 1-year follow-up. The outcome differences were specific for stroke, as stroke centers and nondesignated hospitals had similar 30-day all-cause mortality rates among those with gastrointestinal hemorrhage (5.0% vs 5.8%; adjusted mortality difference, +0.3%; 95% CI, -0.5% to 1.0%; P = .50) or acute myocardial infarction (10.5% vs 12.7%; adjusted mortality difference, +0.1%; 95% CI, -0.9% to 1.1%; P = .83).Among patients with acute ischemic stroke, admission to a designated stroke center was associated with modestly lower mortality and more frequent use of thrombolytic therapy.

Dataset Information

Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke.

Background

Objective

Methods

Results

Conclusion

Publications

Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke.

Similar Datasets

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