Ontology highlight
ABSTRACT:
SUBMITTER: Szojka AR
PROVIDER: S-EPMC7874349 | biostudies-literature | 2021 Jan-Dec
REPOSITORIES: biostudies-literature
Szojka Alexander Ra AR Marqueti Rita de Cássia RC Li David Xinzheyang DX Molter Clayton W CW Liang Yan Y Kunze Melanie M Mulet-Sierra Aillette A Jomha Nadr M NM Adesida Adetola B AB
Journal of tissue engineering 20210101
This study investigates the transcriptome response of meniscus fibrochondrocytes (MFCs) to the low oxygen and mechanical loading signals experienced in the knee joint using a model system. We hypothesized that short term exposure to the combined treatment would promote a matrix-forming phenotype supportive of inner meniscus tissue formation. Human MFCs on a collagen scaffold were stimulated to form fibrocartilage over 6 weeks under normoxic (NRX, 20% O<sub>2</sub>) conditions with supplemented T ...[more]