The effect of diabetes on corneal endothelium: a meta-analysis.

ABSTRACT:

Background

This research was conducted with the aim to determine the effect of diabetes mellitus on corneal endothelial cells.

Methods

The terms: ("diabetes mellitus" or "diabetes" or "diabetic") and ("corneal endothelium" or "cornea" or "Corneas") searched in Pubmed, Embase, Cochrane, and Web of science until August 2019. The included types of studies contained observational studies. The standard mean difference (SMD) which was deemed as main size effects for continuous data was calculated by means and standard deviations. The data on corneal endothelial cell density (ECD), mean cell area (MCA), cell area variation coefficient (CV) and percentage of hexagonal cells (HEX) included in the study were collected and analyzed using stata15.1.

Results

The final 16 cross-sectional studies and 2 case-control studies were included for the meta-analysis. Meta-analysis revealed that diabetes mellitus could reduce ECD (SMD?=?-?0.352, 95% CI -0.538, -?0.166) and the HEX (SMD?=?-?0.145, 95% CI -0.217, -?0.074), in addition to increasing CV (SMD?=?0.195, 95% CI 0.123, 0.268). Nevertheless, there was no statistically significant differences observed when combining MCA (SMD?=?0.078, 95% CI -0.022, 0.178). In subgroup analysis, Type 2 diabetes patients owned less corneal ECD (P?ConclusionsAs indicated by meta-analysis, diabetes mellitus could cause a detrimental effect on corneal endothelium health. Diabetes mellitus contributed to the instability of corneal endothelium during the analysis. Therefore, further research is considered necessary to confirm our research results.

Trial registration

CED 42019145858 .

SUBMITTER: Zhang K 

PROVIDER: S-EPMC7874671 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature