Ontology highlight
ABSTRACT:
SUBMITTER: Pervolarakis N
PROVIDER: S-EPMC7874899 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Pervolarakis Nicholas N Nguyen Quy H QH Williams Justice J Gong Yanwen Y Gutierrez Guadalupe G Sun Peng P Jhutty Darisha D Zheng Grace X Y GXY Nemec Corey M CM Dai Xing X Watanabe Kazuhide K Kessenbrock Kai K
Cell reports 20201001 3
The mammary epithelial cell (MEC) system is a bilayered ductal epithelium of luminal and basal cells, maintained by a lineage of stem and progenitor populations. Here, we used integrated single-cell transcriptomics and chromatin accessibility analysis to reconstruct the cell types of the mouse MEC system and their underlying gene regulatory features in an unbiased manner. We define differentiation states within the secretory type of luminal cells, which forms a continuous spectrum of general lum ...[more]