Ontology highlight
ABSTRACT:
SUBMITTER: Guo W
PROVIDER: S-EPMC7875530 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Guo Weiwei W Wang Yue Y Yang Min M Wang Zehua Z Wang Yifei Y Chaurasia Smriti S Wu Zhiyuan Z Zhang Min M Yadav Ghanshyam Singh GS Rathod Sanjay S Concha-Benavente Fernando F Fernandez Christian C Li Song S Xie Wen W Ferris Robert L RL Kammula Udai S US Lu Binfeng B Yang Da D
Science advances 20210210 7
Through an integrative analysis of the lincRNA expression and tumor immune response in 9,626 tumor samples across 32 cancer types, we developed a lincRNA-based immune response (LIMER) score that can predict the immune cells infiltration and patient prognosis in multiple cancer types. Our analysis also identified tumor-specific lincRNAs, including <i>EPIC1</i>, that potentially regulate tumor immune response in multiple cancer types. Immunocompetent mouse models and in vitro co-culture assays dem ...[more]