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Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?


ABSTRACT: The enduring impact of COVID-19 on patients has been examined in recent studies, leading to the description of Long-COVID. We report the lasting symptom burden of COVID-19 patients from the first wave of the pandemic. All patients with COVID-19 pneumonia discharged from a large teaching hospital trust were offered follow-up. We assessed symptom burden at follow-up using a standardised data collection technique during virtual outpatient clinic appointments. Eighty-six percent of patients reported at least one residual symptom at follow-up. No patients had persistent radiographic abnormalities. The presence of symptoms at follow-up was not associated with the severity of the acute COVID-19 illness. Females were significantly more likely to report residual symptoms including anxiety (p?=?0.001), fatigue (p?=?0.004), and myalgia (p?=?0.022). The presence of long-lasting symptoms is common in COVID-19 patients. We suggest that the phenomenon of Long-COVID may not be directly attributable to the effect of SARS-CoV-2, and believe the biopsychosocial effects of COVID-19 may play a greater role in its aetiology.

SUBMITTER: Sykes DL 

PROVIDER: S-EPMC7875681 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?

Sykes Dominic L DL   Holdsworth Luke L   Jawad Nadia N   Gunasekera Pumali P   Morice Alyn H AH   Crooks Michael G MG  

Lung 20210211 2


The enduring impact of COVID-19 on patients has been examined in recent studies, leading to the description of Long-COVID. We report the lasting symptom burden of COVID-19 patients from the first wave of the pandemic. All patients with COVID-19 pneumonia discharged from a large teaching hospital trust were offered follow-up. We assessed symptom burden at follow-up using a standardised data collection technique during virtual outpatient clinic appointments. Eighty-six percent of patients reported  ...[more]

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