Dataset Information

Protein Farnesylation Takes Part in Arabidopsis Seed Development.

ABSTRACT: Protein farnesylation is a post-translational modification regulated by the ERA1 (Enhanced Response to ABA 1) gene encoding the ?-subunit of the protein farnesyltransferase in Arabidopsis. The era1 mutants have been described for over two decades and exhibit severe pleiotropic phenotypes, affecting vegetative and flower development. We further investigated the development and quality of era1 seeds. While the era1 ovary contains numerous ovules, the plant produces fewer seeds but larger and heavier, with higher protein contents and a modified fatty acid distribution. Furthermore, era1 pollen grains show lower germination rates and, at flower opening, the pistils are immature and the ovules require one additional day to complete the embryo sac. Hand pollinated flowers confirmed that pollination is a major obstacle to era1 seed phenotypes, and a near wild-type seed morphology was thus restored. Still, era1 seeds conserved peculiar storage protein contents and altered fatty acid distributions. The multiplicity of era1 phenotypes reflects the diversity of proteins targeted by the farnesyltransferase. Our work highlights the involvement of protein farnesylation in seed development and in the control of traits of agronomic interest.

SUBMITTER: Verges V

PROVIDER: S-EPMC7876099 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Protein Farnesylation Takes Part in Arabidopsis Seed Development.

Vergès Valentin V Dutilleul Christelle C Godin Béatrice B Collet Boris B Lecureuil Alain A Rajjou Loïc L Guimaraes Cyrille C Pinault Michelle M Chevalier Stéphane S Giglioli-Guivarc'h Nathalie N Ducos Eric E

Frontiers in plant science 20210128

Protein farnesylation is a post-translational modification regulated by the ERA1 (Enhanced Response to ABA 1) gene encoding the β-subunit of the protein farnesyltransferase in Arabidopsis. The era1 mutants have been described for over two decades and exhibit severe pleiotropic phenotypes, affecting vegetative and flower development. We further investigated the development and quality of era1 seeds. While the era1 ovary contains numerous ovules, the plant produces fewe ...[more]

PMID: 33584774

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Project description:PurposeThe 'Bikeability' cycle training scheme, a flagship policy of the government in England, aims to give children the skills and confidence to cycle more safely and more often. Little, however, is known about the scheme׳s reach. This paper examined which schools offer Bikeability, and which children participate in cycle training.MethodsWe used operational delivery data to examine which primary schools in England offered Bikeability. Predictors included the deprivation level of the student body and the local prevalence of cycling. We then examined cycle training participation using data from 6986 participants (age 10-11) in the nationally-representative Millennium Cohort Study. Parents reported whether their child had completed formal cycle training, along with other child and family factors. We used operational data to identify children whose school had previously delivered Bikeability.Results55% of schools offered Bikeability to the cohort of children leaving primary school in 2012; this fell to 48% in schools in the top tenth for student deprivation. Among Millennium Cohort participants, 47% of children had completed cycle training; this proportion rose to 68% among children whose schools had offered Bikeability. In adjusted robust Poisson regression models, participation rates were lower among minority ethnic children, particularly South Asians; among children who played sport less often; and among children whose parents were poorer or less educated. The magnitude of these differences was largest among children whose schools had not offered Bikeability (all p≤0.02 for interaction, except for income where p=0.09), although trends in the same direction were observed in schools that had offered Bikeability.ConclusionsOffering high-quality cycle training free of charge in English schools reduced but did not eliminate inequalities in cycle training participation. Further promoting the scheme to parents and schools, particularly in deprived areas, would be expected to increase uptake and help reduce current inequalities in participation.

Dataset Information

Protein Farnesylation Takes Part in Arabidopsis Seed Development.

Publications

Protein Farnesylation Takes Part in Arabidopsis Seed Development.

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