Untargeted analysis of first trimester serum to reveal biomarkers of pregnancy complications: a case-control discovery phase study.

ABSTRACT: Understanding of causal biology and predictive biomarkers are lacking for hypertensive disorders of pregnancy (HDP) and preterm birth (PTB). First-trimester serum specimens from 51 cases of HDP, including 18 cases of pre-eclampsia (PE) and 33 cases of gestational hypertension (GH); 53 cases of PTB; and 109 controls were obtained from the Global Alliance to Prevent Prematurity and Stillbirth repository. Metabotyping was conducted using liquid chromatography high resolution mass spectroscopy and nuclear magnetic resonance spectroscopy. Multivariable logistic regression was used to identify signals that differed between groups after controlling for confounders. Signals important to predicting HDP and PTB were matched to an in-house physical standards library and public databases. Pathway anal

SUBMITTER: Harville EW 

PROVIDER: S-EPMC7876105 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature