Genetic determinants of daytime napping and effects on cardiometabolic health.

ABSTRACT: Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n?=?452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n?=?541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference.

SUBMITTER: Dashti HS 

PROVIDER: S-EPMC7876146 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature