Ontology highlight
ABSTRACT:
SUBMITTER: Cui H
PROVIDER: S-EPMC7876337 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in immunology 20210128
SARS-CoV-2 causes the ongoing COVID-19 pandemic. Natural SARS-COV-2 infection has been detected in dogs, cats and tigers. However, the symptoms in canines and felines were mild. The underlying mechanisms are unknown. Excessive activation of inflammasome pathways can trigger cytokine storm and severe damage to host. In current study, we performed a comparative genomics study of key components of inflammasome and pyroptosis pathways in dogs, cats and tigers. Cats and tigers do not have AIM2 and NL ...[more]