Ontology highlight
ABSTRACT:
SUBMITTER: Sheng Y
PROVIDER: S-EPMC7876501 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Sheng Yujun Y Zhang Jiali J Li Keke K Wang Hongyan H Wang Wenjun W Wen Leilei L Gao Jinping J Tang Xianfa X Tang Huayang H Huang He H Cai Minglong M Yuan Tao T Liu Lu L Zheng Xiaodong X Zhu Zhengwei Z Cui Yong Y
FEBS open bio 20201222 2
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by abnormal activation of T cells and caused by an imbalance in the production and clearance of apoptotic cells. We previously showed that the transcription regulator Bach2 regulated abnormal B-cell activation in SLE. Here, we investigated whether Bach2 was also involved in Th9 cell differentiation in SLE. We found that the proportion of Th9 cells was enhanced in the peripheral blood mononuclear cells (PBMC) of SLE ...[more]