High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure.

ABSTRACT:

Purpose

Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess the effect of high-flow nasal oxygen on ventilator-free days, compared to early initiation of invasive mechanical ventilation, on adult patients with COVID-19.

Methods

We conducted a multicentre cohort study using a prospectively collected database of patients with COVID-19 associated acute respiratory failure admitted to 36 Spanish and Andorran intensive care units (ICUs). Main exposure was the use of high-flow nasal oxygen (conservative group), while early invasive mechanical ventilation (within the first day of ICU admission; early intubation group) served as the comparator. T

SUBMITTER: Mellado-Artigas R 

PROVIDER: S-EPMC7876530 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature