Ontology highlight
ABSTRACT:
SUBMITTER: Carugo A
PROVIDER: S-EPMC7876656 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cancer cell 20190201 2
Alterations in chromatin remodeling genes have been increasingly implicated in human oncogenesis. Specifically, the biallelic inactivation of the SWI/SNF subunit SMARCB1 results in the emergence of extremely aggressive pediatric malignancies. Here, we developed embryonic mosaic mouse models of malignant rhabdoid tumors (MRTs) that faithfully recapitulate the clinical-pathological features of the human disease. We demonstrated that SMARCB1-deficient malignancies exhibit dramatic activation of the ...[more]