Ontology highlight
ABSTRACT:
SUBMITTER: Carugo A
PROVIDER: S-EPMC7876656 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Carugo Alessandro A Minelli Rosalba R Sapio Luigi L Soeung Melinda M Carbone Federica F Robinson Frederick S FS Tepper James J Chen Ziheng Z Lovisa Sara S Svelto Maria M Amin Samirkumar S Srinivasan Sanjana S Del Poggetto Edoardo E Loponte Sara S Puca Francesca F Dey Prasenjit P Malouf Gabriel G GG Su Xiaoping X Li Liren L Lopez-Terrada Dolores D Rakheja Dinesh D Lazar Alexander J AJ Netto George J GJ Rao Priya P Sgambato Alessandro A Maitra Anirban A Tripathi Durga N DN Walker Cheryl L CL Karam Jose A JA Heffernan Timothy P TP Viale Andrea A Roberts Charles W M CWM Msaouel Pavlos P Tannir Nizar M NM Draetta Giulio F GF Genovese Giannicola G
Cancer cell 20190201 2
Alterations in chromatin remodeling genes have been increasingly implicated in human oncogenesis. Specifically, the biallelic inactivation of the SWI/SNF subunit SMARCB1 results in the emergence of extremely aggressive pediatric malignancies. Here, we developed embryonic mosaic mouse models of malignant rhabdoid tumors (MRTs) that faithfully recapitulate the clinical-pathological features of the human disease. We demonstrated that SMARCB1-deficient malignancies exhibit dramatic activation of the ...[more]