In silico design of multi-epitope-based peptide vaccine against SARS-CoV-2 using its spike protein.

ABSTRACT: SARS-CoV-2 has been efficient in ensuring that many countries are brought to a standstill. With repercussions ranging from rampant mortality, fear, paranoia, and economic recession, the virus has brought together countries to look at possible therapeutic countermeasures. With prophylactic interventions possibly months away from being particularly effective, a slew of measures and possibilities concerning the design of vaccines are being worked upon. We attempted a structure-based approach utilizing a combination of epitope prediction servers and Molecular dynamic (MD) simulations to develop a multi-epitope-based subunit vaccine that involves the two subunits of the spike glycoprotein of SARS-CoV-2 (S1 and S2) coupled with a substantially effective chimeric adjuvant to create stable vaccine

SUBMITTER: Mitra D 

PROVIDER: S-EPMC7876912 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature