Ontology highlight
ABSTRACT:
SUBMITTER: Schmit T
PROVIDER: S-EPMC7877192 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Schmit Taylor T Kuntz Mikale M Patel Devarshi D Nadeem Khan M M
Vaccine 20201219 3
We evaluated the effectiveness of anti-22F serotype immunity in the prevention of Streptococcus pneumoniae (Spn) bacterial transmission during colonization and influenza virus co-infection. Mice were immunized with 22F formulation and later colonized with Spn or co-infected with Spn and influenza virus. The 22F antisera exhibited strong reactivity to 22F bacteria and promoted the opsonic uptake of Spn by the neutrophils. The 22F vaccination led to a significant reduction of bacterial densities i ...[more]