Ontology highlight
ABSTRACT:
SUBMITTER: Daemen S
PROVIDER: S-EPMC7877246 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Cell reports 20210101 2
Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding, mature TIM4<sup>pos</sup> Kupffer cells (KCs) decrease in number, while monocyte-derived Tim4<sup>neg</sup> macrophages accumulate. In concert, monocyte-derived infiltrating macrophages enter the liver and consist of a transitional subset that expresses Cx3cr1/Ccr2 and a second subset characterized by expression of Trem2, Cd63 ...[more]