Ontology highlight
ABSTRACT:
SUBMITTER: Yan L
PROVIDER: S-EPMC7877347 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Yan Lingzhi L Qu Su S Shang Jingjing J Shi Xiaolan X Kang Liqing L Xu Nan N Zhu Mingqing M Zhou Jin J Jin Song S Yao Weiqin W Yao Ying Y Chen Guanghua G Chang Huirong H Zhu Xiaming X Yu Lei L Wu Depei D Fu Chengcheng C
Cancer medicine 20201223 2
The low rate of durable response against relapsed and/or refractory multiple myeloma (RRMM) in recent studies indicates that chimeric antigen receptor T-cell (CART) treatment is yet to be optimized. This study aims to investigate the safety and efficacy of sequential infusion of CD19-CART and B-cell maturation antigen (BCMA)-CARTs for RRMM with a similar 3 + 3 dose escalation combined with a toxicity sentinel design. We enrolled 10 patients, among whom 7 received autologous infusion and 3 receiv ...[more]