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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors.


ABSTRACT: The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa is poorly described. The first case of SARS-CoV-2 in Kenya was reported on 12 March 2020, and an overwhelming number of cases and deaths were expected, but by 31 July 2020, there were only 20,636 cases and 341 deaths. However, the extent of SARS-CoV-2 exposure in the community remains unknown. We determined the prevalence of anti-SARS-CoV-2 immunoglobulin G among blood donors in Kenya in April-June 2020. Crude seroprevalence was 5.6% (174 of 3098). Population-weighted, test-performance-adjusted national seroprevalence was 4.3% (95% confidence interval, 2.9 to 5.8%) and was highest in urban counties Mombasa (8.0%), Nairobi (7.3%), and Kisumu (5.5%). SARS-CoV-2 exposure is more extensive than indicated by case-based surveillance, and these results will help guide the pandemic response in Kenya and across Africa.

SUBMITTER: Uyoga S 

PROVIDER: S-EPMC7877494 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors.

Uyoga Sophie S   Adetifa Ifedayo M O IMO   Karanja Henry K HK   Nyagwange James J   Tuju James J   Wanjiku Perpetual P   Aman Rashid R   Mwangangi Mercy M   Amoth Patrick P   Kasera Kadondi K   Ng'ang'a Wangari W   Rombo Charles C   Yegon Christine C   Kithi Khamisi K   Odhiambo Elizabeth E   Rotich Thomas T   Orgut Irene I   Kihara Sammy S   Otiende Mark M   Bottomley Christian C   Mupe Zonia N ZN   Kagucia Eunice W EW   Gallagher Katherine E KE   Etyang Anthony A   Voller Shirine S   Gitonga John N JN   Mugo Daisy D   Agoti Charles N CN   Otieno Edward E   Ndwiga Leonard L   Ndwiga Leonard L   Lambe Teresa T   Wright Daniel D   Barasa Edwine E   Tsofa Benjamin B   Bejon Philip P   Ochola-Oyier Lynette I LI   Agweyu Ambrose A   Scott J Anthony G JAG   Warimwe George M GM  

Science (New York, N.Y.) 20201111 6524


The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa is poorly described. The first case of SARS-CoV-2 in Kenya was reported on 12 March 2020, and an overwhelming number of cases and deaths were expected, but by 31 July 2020, there were only 20,636 cases and 341 deaths. However, the extent of SARS-CoV-2 exposure in the community remains unknown. We determined the prevalence of anti-SARS-CoV-2 immunoglobulin G among blood donors in Kenya in April-June 2020. Crude s  ...[more]

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